Posts Tagged ‘drug detox’

Opiate Detoxification

 
 
Medical Detoxification is a process in which individuals are systematically and safely withdrawn from addicting drugs, usually under the care of a physician. Drinking alcohol or using drugs causes physical dependence over time in some people. Stopping the use of alcohol or drugs results in physical withdrawal from these substances in people with a physical dependence. The detoxification process is designed both to treat the acute physiological effects of stopping drug use and to remove residual toxins in the body left as a result of using the chemicals found in drugs and/or alcohol.

Medical Detoxification: In order to withdraw from certain addictive substances safely, it may be preferable and in some cases necessary to undergo medically supervised detoxification in a hospital or residential treatment center that has a detoxification unit. This would be advisable for patients that have been using an addictive substance heavily for a longer period of time and are more likely to have more severe withdrawal symptoms, or those with other significant health problems. Inpatient detoxification allows the patient to be closely monitored throughout the process and given appropriate medication to prevent severe withdrawal symptoms. It commonly involves the gradual administration of decreasing doses (tapering) of an agent that is related to the original drug of abuse that is now substituted to prevent withdrawal.

Rapid Detoxification: In this procedure drug withdrawal occurs while patients are asleep under general anesthesia. The patient is given intravenous injections of medications called opiate blockers which stop the action of narcotics and opiate drugs as well as injections of other medications that reduce the symptoms of withdrawal such as muscle relaxants or anti-nausea medications. This process results in rapid withdrawal from the physical effects of addiction. Through the use of opiate blockers such as naltrexone, naloxone, and nalmephine, physical detoxification is achieved within 4 to 8 hours. Rapid detox takes place in an intensive care unit of a hospital. Patients are usually discharged within 48 hours following recovery from anesthesia and assessment of their physical status.

Rapid detoxification helps reduce the distress of opiate withdrawal for people who are chemically dependent on narcotics such as heroin, Vicodin, Percocet, Demerol, Dilaudid, Darvocet, OxyContin, opium, morphine, codeine, oxycodone, hydrocodone, prescription painkillers, and all narcotic type drugs. It shortens the detoxification period and spares patients the pain and physical discomforts of withdrawal. It may be of great benefit to patients who suffer from severe withdrawal symptoms and who have failed repeatedly to complete conventional withdrawal programs . However, there are significant costs as well as risks associated with the use of general anesthesia. It is imperative that the procedure be performed by medical professionals who are highly trained in these procedures in a medical setting that is fully equipped to deal with any complications that may arise.

Stepped Rapid Detoxification: This alternative to rapid detoxification provides small doses of Narcan (Naloxone) subcutaneously and naltrexone orally every hour or so, together with reduced withdrawal management medications , mostly orally, as necessary. This approach using the slower oral and subcutaneous routes rid the body of the opiate more slowly than intravenous Rapid Detoxification . In addition the pacing can be controlled and responsive to any withdrawal symptoms that develop in the patient by having them quickly suck on Buprenorphine tablets under the tongue. There is less need for withdrawal management medications. The patient is alert and directly communicating with medical staff until the situation has been resolved. It is possible to be detoxified and stabilized on Naltrexone Maintenance Therapy with 2 to 4 small manageable bites. If someone tries to use any kind of opiate while they are on Naltrexone, they feel no effect because all of the receptors are completely blocked.

Ultra Rapid Detoxification: This procedure involves putting patients under general anesthesia and giving them a drug called Naltrexone which blocks all of their endorphin receptors. This accelerates the withdrawal process, pushing them into 100% detoxification within a 5-30 minute period. Although this is an extremely painful process it is tolerable under anesthesia. As with rapid detoxification, it is very costly and has significant medical risk.

Outpatient Detoxification
Outpatient medical detoxification is usually safe and effective for people who are more likely to have mild to moderate withdrawal symptoms. For instance, primary care-based opiate detoxification can be accomplished with a variety of medications such as buprenorphine-naloxone (BUP/NX) or clonidine alone or combined with naltrexone. Buprenex, newly approved by the FDA, can now be administered on an outpatient basis by physicians who receive a required eight-hour training. Using Buprenex, the detoxification can take between 7-14 days.

Opiate and Heroin Detox Programs

Heroin and opiates are physically addicting. Heroin detox becomes necessary when the body adapts to the presence of the drug and more and more is needed to reduce the cravings for the drug. Withdrawal symptoms will definitely occur if heroin use or opiate use is abruptly discontinued.

Generally speaking, withdrawal from heroin and other opiates may occur as early as a few hours after the last use. The withdrawal symptoms of heroin addiction include:

  •  drug craving
  •  restlessness
  •  muscle and bone pain
  • insomnia
  • diarrhea
  • vomiting
  • sweats and cold flashes

Major withdrawal symptoms of heroin addiction and other opiate addictions peak between 48 and 72 hours after the last dose. Without proper medical care seizures or convulsions can occur. The good news is that an addict can usually complete heroin detox or opiate detox within five and seven days.

Choose Inpatient Heroin Detox or Opiate Detox Programs

Heroin detox and opiate detox can be a very challenging process both physically and emotionally. It is my opinion that anyone undergoing heroin detox or opiate detox, should do so in drug rehab programs or addiction treatment programs that specialize in medical detox programs. All heroin detox programs should be medically monitored, complete with 24 hour nursing, able to dispense medications as needed and directed by a physician trained in addiction medicine (addictionologist).

Ongoing Addiction Treatments

Even after heroin or opiate detox is complete, many people require ongoing addiction treatments, therefore heroin detox should take place within one of many drug rehab centers or addiction treatment programs. Drug rehab programs provide a smoother transition from heroin detox and opiate detox programs, which are medically driven, into a clinically driven level of care within the drug rehab.

Structure is Key

Another reason we feel that heroin detox should be provided within the confines of drug rehab programs or addiction treatment programs is due to the structure they provide. Many people attempt heroin detox on an outpatient basis. While outpatient heroin detox can work for some, most addicts require the structure of inpatient detox programs to deal with the cravings and keep them away from their environment, old friends and access to opiates.

While in the grips of heroin or opiate addiction, addicts are often involved in high risk activities. By undergoing opiate detox or heroin detox in drug rehab centers, addicts receive a comprehensive physical examination. This will help identify any medical problems that are present and need to be addressed. This examination process is begun in detox and ongoing support is available if a person transitions into drug rehab.

Top 5 Reasons why Interventions Fail

A successful intervention can lead a person you love toward a drug rehab treatment program that can help them improve their lives and bring happiness and relief to those around him. However, many interventions fail because the families of those afflicted by drug addiction do not know how to lead a successful intervention. Certain factors must be in place and followed in order to get the addict to a drug rehab. Treatment may seem impossible if the addict isn’t willing to seek help. However, a formal intervention will work if done in the proper way.

After spending time interviewing several interventionists and intake counselors from various drug rehab treatment programs, I have come up with the top 5 reasons why an intervention would fail:

1. Failure to use a Professional: This may sound pitch for interventionists, but the plain fact is that most family members are not accustomed to confronting and addressing problems easily amongst themselves. They may carry guilt from the past, bring up unresolved and unrelated issues and the entire situation may turn into a screaming match which results in nothing but pain for everyone. Interventions can get so ugly that the exact opposite effect occurs, that the addict refuses help and swears off his family and jumps deeper into his own self-destruction.

Many drug rehab programs have staff trained to facilitate an intervention, or can refer you to one. These individuals guide the intervention towards the ultimate goal, which is to get your loved one to a drug rehab treatment center. They bring an unbiased opinion to what is bound to be an emotional and difficult situation for those involved and are able to see things far in advance and can lead the way towards success.

2. Wavering from the Determined Goal: Ultimately, you want your loved one to check into a drug rehab. Treatment is the only option if you are even considering an intervention, not meetings or to let him do it on his own. Do not lose focus on this once the intervention starts and make sure that all involved are willing to do what it takes to make this happen. Sometimes the addict will shift blame to other family members and try to take on the role of a victim. This can be a powerful tool of manipulation as there may be truth or guilt connected to it. Once this happens, family members start to negotiate with the addict or doubt themselves. This will have disastrous effects on the success of the intervention.

Regardless of what “dirty laundry” may come out on the table, the fact of the matter is that the addict is the one that needs help the most and although everyone may have problems in life, the addict is the one who the focus must be on. He may do or say terrible and hurtful things to get our of the intervention and back onto drugs and that must not happen.

3. A Family Divided: Involve all members of the family in the intervention planning, providing they are there to help. Ensure that everyone who will be attending is in agreement with the ultimate goal of getting the addict to a drug rehab treatment center. If one family isn’t on board, he may secretly tell the addict about the intervention in advance or may take sides with addict, thus weakening the argument for treatment and ensuring a failure. If the family members doing the intervention are bitter towards each other, the addict can turn the entire meeting into a circus of finger-pointing in order to escape the situation.

There must always be an ultimatum which is: Drug Rehab Treatment or nothing. This can be difficult for a mother who doesn’t want to “see her baby on the street” or a father who knows his son or daughter “can’t survive on their own”. If the addict knows that the parents will cut him off but the grandparents will ALWAYS take him in no matter what, the leverage is lost. If all family members have the same goal in mind and stick together, the better chance the intervention has of succeeding. After all, the idea is to HELP the addict, right? Enabling someone to continue their lifestyle of self-destruction is hardly help but a silent condoning of it.

4. Failure to have an Immediate Plan of Action.Prior to the intervention, make sure you have a plan of action that will actually get your loved one to a drug rehab where he can be treated for his addiction. Often the addict will agree to go to treatment “later” after he “takes care of a few things”. Offer to take care of those things for him so that it is one less thing to worry about. He may make excuses as to why he can’t go now; his job is too important or his school is almost done. In fact, he may convince you that his considerations are valid and it can seem like there really is no way her can go.

However, you must not let that happen. The odds are against him that he will actually make it to the drug rehab treatment center. Have a plane ticket, a ride, and an escort ready to get him there within 24 hours after the intervention takes place. You may be able to stretch this time to 48 hours at the VERY LATEST, but make sure the addict has close supervision the entire time. I spoke to several parents who were devastated after they allowed their child to put off treatment until some “important things” were taken care of, only to find their child had overdosed. Not one of these parents felt that it was worth it to wait to get the addict into treatment and all of them regretted not doing whatever they could to get their child into the drug rehab. Also, none of them foresaw the danger the addict was really in.

5. Inadequate Research of Drug Rehab Treatment. There are many types of drug rehab treatments out there and it is important to research which one will best help the addict in your life. Once you have made a decision, get in contact with the drug rehab treatment center and let them know about the intervention and you can often get some great advice. Have some of their literature on hand during the intervention, so the addict realizes that drug rehab is not prison, but simply a place to change your life.

Every drug rehab program has rules, and rightly so. Learn what they will allow and not allow. For instance, some programs do not allow cigarette smoking. If the addict smokes, this program would not be a good choice. If the intervention is on the right track, having this information immediately available will help speed the process along.

An intervention can seem overwhelming and frightening to the family of an addict and should not be underestimated. However, it can be successful if the reasons above are resolved and the corresponding steps above are followed. There is hope in getting your loved one into a type of a drug rehab treatment program that changes their lives for the better.

Source: Narconan by John Frank

Mom Hits Bottom After Years of Drinking

Lynn Wardlow says concern for her health and family helped convince her to quit.

At the end of a country road, inside the walls of a quaint and calm Hattiesburg, Miss., home, a family was in crisis.

Lynn Wardlow, a 50-year-old wife and mother of three, had been a drinker for more than 20 years. All the while, though, she ran a family business and raised her children.

In January, “20/20? visited Wardlow. It was the day before she’d planned to give up alcohol for good.

“My hands are shaking,” said Wardlow as she packed her bags. “God, I hope I remembered to bring underwear.”

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In the morning, Wardlow would travel from the Gulf Coast to Palm Beach, Fla., check herself into a medical facility for detox and then enter a 30-day rehab program for her alcohol addiction.

Meanwhile, Wardlow planned one last hurrah. She took a bottle from a cabinet in her bedroom.

“Would this be my best choice for my last bottle of wine?” she asked.

The last year in the Wardlow home had been particularly difficult, especially for the children — Bo, 21; Jessy, 20; and Marina, 17.

“She’s been drinking every night for as far back as I don’t even know,” said Bo. “The last year there’s been a lot of drama, and it’d be nice if things were just normal for even just a little while.”

Wardlow poured herself some wine. “My kids want me to just stop, stop, stop, but I like, I don’t think I can just stop,” she said.

“And if I did, I don’t know if I would feel very good, or if we might have to go to the hospital, because I just stopped after I’ve been going, go, go, go for so long.”

Wardlow’s children have witnessed things no child should ever see: their mother passed out in her closet, in a drunken rage at a bookstore, in a car attempting to drive after an alcohol-infused fight.

“It’s hard to see someone you love have to be addicted to something in order to feel better,” said Marina.

“It makes you feel like you’ve done something wrong,” said Jessy.

Drunken Moms: ‘When She Gets Like That’

The kids say their mother’s drinking had reached a critical point. Last April, Wardlow was diagnosed with hepatitis C, unrelated to her alcoholism. Unless she quit drinking, she could die.

But even the threat of losing her life, the family said, hadn’t stopped Wardlow from consuming alcohol.

“I want my mom to get better and not just for our sake but for her sake for her health,” said Jessy.

Wardlow’s last night at home was tense. The alcohol fueled her anxiety of what was to come.

“I think after two drinks, I’m like, you know what, these people aggravate me,” said Wardlow, who ran the family’s ceiling construction business. “And they aggravate me during the course of the day, and at the end of the day, I have a couple of drinks.”

The kids knew better than to stick around once Lynn started drinking. Wardlow’s husband, Bob, soon became a target.

“If you want to spend more time with Bill O’Reilly and your computer then go ahead,” Wardlow cracked.

“When she gets like that, conversations can turn to arguments,” said Bob.

“Or being an a**hole can turn to arguments,” said Wardlow. “Maybe I’m just able to say, you know what, [I've] had it up to here!”

The next morning, her head a little clearer, Wardlow acknowledged that rehab may be her last chance.

“I’ve affected my children. … Our relationships would be different if alcohol wasn’t a part of my life,” she said.

But just before she walked out the door, the leftover wine from the night before called to her.

“I’m not going to drink that,” Wardlow said, wavering before she gave in and took a sip.

Wardlow’s family walked her down the steps. She gave them kisses. She grew emotional.

“I’m not the only person who needs to be healed,” said Wardlow. “I’m not the only person who has been affected by this.

“It’s gonna be good,” she assured her famliy. “I’m going to get better.”

Two planes, three bloody mary’s and two beers later, Wardlow landed in Florida.

She was greeted by Loren Seaman from the Orchid Recovery Center, where Wardlow would surrender herself for treatment.

“Did you drink?” Seaman asked.

“Well, hell yeah,” Wardlow said.

Wardlow and Seaman had been talking for weeks on the phone to prepare for her arrival.

But before her bags had even make it downstairs, a shoeless Wardlow headed off for one more drink.

“We’re going to make a new martini,” Wardlow said. “It’s called the Lynn’s-quitting-drinking-and-going-to-rehab martini. Ready?

Drunken Moms: Tough Recovery Odds

Finally, it was time for Seaman to sign Wardlow into the center.

“Have you ever been to detox?” Seaman asked. The answer was no.

“It’s OK, I’m good,” said Wardlow, laughing. “I’m drunk, so right now I ain’t scared. Give me a day or two, and I’m probably going to be frightened out of my wits.”

Over a million people submit to detox and rehab programs for alcohol addiction every year in this country. The odds going into rehab were against Wardlow. Studies show that 90 percent of people in recovery relapse.

Wardlow had a session with Linda Burns, head of nursing at Sunrise Detox.

“How much are you drinking a day, about?” Linda asked.

“Four, five, six …” replied Wardlow.

According to the National Institute on Alcohol Abuse, one third of alcoholics in the United States are women.

Staff at both the Orchid and Sunrise Detox Center told “20/20? that about 95 percent of the women they pick up at the airport are intoxicated upon arrival. Wardlow was no exception.

A Sunrise Detox tech measured Wardlow’s blood alcohol content upon admission.

“You’re not too bad — .106,” the tech said.

“What does that mean?” said Wardlow. “Would I be arrested?”

“Oh, definitely, yeah.”

“I would be arrested.”

“Yeah.”

“Point-zero-8 is the limit, and I’m at point 1-plus over. I’m over the limit to drive a vehicle.”

“Yes, you would be wearing nice bracelets.”

For the next five days — standard for alcohol addiction — Wardlow remained at Sunrise. She was medicated with a drug called librium to eliminate the side effects of withdrawal, which can range from tremors and insomnia to delirium or even seizures.

From day one, Wardlow was restless.

“If you reached in your pocket right now and pulled out a beer, it would be really hard for me not to drink it,” she told “20/20.” “Quite honestly, it would.”

By day four, her impatience and boredom reached all-time highs.

“I have not had a good morning,” she said, talking to a portable camera “20/20? gave her to document her journey. “I have cried on more than one occasion today. I have come to the realization that this is the closest thing to a jail that I have ever been in.”

But it was only the beginning of a long and difficult journey.

The next step for Wardlow was the Orchid Recovery Center, a drug and alcohol rehabilitation center designed specifically to treat women.

“We’re just glad you’re here, Lynn,” said an Orchid staff member who welcomed her.

“Thank you,” said Wardlow. “I’m glad I’m here too.”

Drunken Moms: From Detox to Rehab

Normally, TV cameras are not permitted to see inside the walls of a rehab facility. But with Wardlow’s permission, the Orchid Recovery Center allowed “20/20? unprecedented access to their treatment process.

“You don’t know Lynn clean and sober,” Mindy Appel, Wardlow’s therapist at the Orchid, told her. “You don’t know that woman.”

Unlike at detox, Wardlow’s days at rehab would be packed, from six in the morning until nine at night. She would have individual and group therapy sessions mixed with yoga, meditation, accupuncture and art.

An all-female facility, the Orchid is run almost exclusively by women, many of whom have been through some type of addiction recovery of their own.

The Orchid places enormous weight on the honing of life skills, encouraging women to shop and cook for themselves — all of the things they’ll have to do back home. But sometimes, even a simple trip to the grocery store can spell trouble. Once a woman from the center drank vanilla extract from the store. It’s 24 percent alcohol. The woman drank five or six big bottles, staff said — and came back reeking of alcohol and walking funny.

For recovering alcoholics, triggers to resume drinking can be anything from beer commercials on TV to the wine store they used to frequent — anything that reminds them of drinking, said Orchid staff.

Wardlow’s heavy lifting for the next 30 days would happen inside the office of Appel, her therapist.

“We want to stay really focused, and I’m going to keep you on task here,” Appel told her.

During her first session, Wardlow confessed her reasons for drinking went back to her relationship with her father.

“So what was growing up like for you?” asked Appel.

“I had times of sadness,” said Wardlow. “My father was an alcoholic… When I was 15 he decided it was time to go … so he died.”

Genetics may also have had a role in Wardlow’s addiction. Studies show that children of alcoholics are four times more likely to develop the problem.

A week into her treatment, “20/20? co-anchor Elizabeth Vargas paid a visit to Wardlow at Orchid. She appeared more calm and focused but still struggled with her addiction.

Vargas asked her if it was hard.

“It’s really hard,” she said. “It is hard and it’s, and it’s hurtful, and you realize how many people that you’ve hurt. And my children are amazing. I mean, I look at them, and I know I’ve not been a bad mother. I’m like, I know I’m a good mother. I’ve mothered them well — but how much better could it have been if these past 10 years, I hadn’t been living in the bottom, in the bottom of a bottle?”

Wardlow described the cycle of her drinking.

“I wake up the next morning, you feel horrible, and you say, ‘I’m gonna do better. I’m gonna do better. I’m gonna do better. So, but I don’t feel very good today. So this afternoon, I’m just gonna have a beer.’” Which turns into “three or four or five or six.”

Are Mothers Drinking More?

The team of therapists at the Orchid said regrets and expectations about being the perfect mother are often what push a woman deeper into her addiction.

“There’s so many women that are so sophisticated at covering up and being, you know, the PTA mom and being the soccer mom and doing all things for everyone,” said Appel.

But are women, particularly mothers, drinking more — or are we just finding out about it more?

“I think we’re finding out about it more,” said Mindy Agler, another therapist on the Orchid team. “[It's] just not something you talk about. … If a man walks away from a family because he needs to focus on his recovery, everybody says OK, so he needs to do that. But if a woman leaves her family to go get treatment and then decides ‘You know what, I’m not ready, I got to go to a halfway house before I go back to my kids,’ everybody goes, ‘Oh my God.’”

That double standard and the stigma of alcoholism can keep a woman’s disease under wraps. But past traumas, the therapists say, can also play a role.

In her short time at the Orchid, Wardlow opened up about not only her alcoholic father but other traumatic experiences: an abortion at 17, and a horrific gang-rape on her 18th birthday.

“She identifies, from 15 to 18, these were horrible years for her,” said Appel. “That she’s never, never dealt with.”

The entire time, a question hung in the background: Would Wardlow make it through treatment, and would she be able to stay away from alcohol once she was back home?

“I’ll be honest with you, I’m scared as hell,” she said. “I’m scared, I’m scared to go home.

Wardlow left the Orchid with 30 days clean and a lifetime of hurdles in front of her. We visited Wardlow in Hattiesburg after her release. She was ready to add another day to her sobriety.

“This is my little tablet,” she said, indicating a pad of paper. “And I wad up yesterday and I write today down, put my little tablet back up there, and if I drink, I have to put that tablet on zero — and I don’t want to have to do that.”

The time back home had not always been easy.

“We had to relearn how to live with one another,” said Wardlow. “The first week or two was pretty volatile. Not in a physical way, but there was lots of screaming and gnashing of teeth.”

But there are signs of healing.

“We’re all really proud of her,” said Marina. “I know if she sets her mind to anything, that’s what she’s going to do. I’m just glad that she finally set her mind to it.”

“I think she’s trying to be more aware, and I think she’s trying to make up for, in some aspects, everything that’s happened and stuff,” said Jessy. “But I think she’s working on it. … I think she’ll do it. I believe in her.”

Wardlow had followed her care plan closely. She had daily phone calls with her sponsor and attended support group meetings regularly.

To stay with the recovery program, Wardlow can never consume a drop of alcohol — or take any habit-forming medication — again.

“No mood-altering drugs, as far as any type of benzos or opiates or whatever,” she said. “I was on tremizal for joint pain. Also I was taking lunesta to sleep, and I’m not taking that any more either.”

Wardlow left one support meeting with a chip marking how long it had been since she’d stopped drinking.

“Ninety days! 90 Days,” she said. “Big three months. Three months sober.”

By SEAN DOOLEY and SHANA DRUCKERMAN

Anti-anxiety drugs (tranquilizers, benzodiazepines)

Anti-anxiety drugs, also known as tranquilizers, are medications that relieve anxiety by slowing down the central nervous system. Their relaxing and calming effects have made them very popular: anti-anxiety drugs are the most widely prescribed type of medication for anxiety. They are also prescribed as sleeping pills and muscle relaxants.

Benzodiazepines are the most common class of anti-anxiety drugs. They include:

Benzodiazepines are fast acting—typically bringing relief within thirty minutes to an hour. Because they work quickly, benzodiazepines are very effective when taken during a panic attack or another overwhelming anxiety episode. But despite their potent anti-anxiety effects, they have their drawbacks.

Side effects of anti-anxiety drugs

Anti-anxiety drugs like benzodiazepines work by reducing brain activity. Understandably, this leads to side effects beyond anxiety relief.

The higher the dose, the more pronounced these side effects typically are. But some people feel sleepy, foggy, and uncoordinated even on low doses of benzodiazepines, which can cause problems with work, school, or everyday activities such as driving. Some even feel a medication hangover the next day.

Because benzodiazepines are metabolized slowly, the medication can build up in the body when used over longer periods of time. The result is oversedation. People who are oversedated may look like they’re drunk.

Common side-effects of benzodiazepines or tranquilizers

  • Drowsiness, lack of energy
  • Clumsiness, slow reflexes
  • Slurred speech
  • Confusion and disorientation
  • Depression
  • Dizziness, lightheadedness
  • Impaired thinking and judgement
  • Memory loss, forgetfulness
  • Nausea, stomach upset
  • Blurred or double vision

Benzodiazepines are also associated with depression. Long-term benzodiazepine users are often depressed, and higher doses are believed to increase the risk of both depressive symptoms and suicidal thoughts and feelings. Furthermore, benzodiazepines can cause emotional blunting or numbness. The medication relieves the anxiety, but it also blocks feelings of pleasure or pain.

Paradoxical effects of anti-anxiety drugs

Despite their sedating properties, some people who take anti-anxiety medication experience paradoxical excitement. The most common paradoxical reactions are increased anxiety, irritability, and agitation. However, more severe effects can also occur, including:

  • Mania
  • Hostility and rage
  • Aggressive or impulsive behavior
  • Hallucinations

While rare, these adverse effects are dangerous. Paradoxical reactions to these anxiety medications are most common in children, the elderly, and people with developmental disabilities.  Many times users of benzodiazepines find that they need to enter an inpatient detox center in order to come off of them.

South Florida Pain Clinics are killing people with Oxycontin

Oxycontin Detox is possible with professional help from a Medical Detox.

Do Genetics Cause Drug Addiction?

The role of genetics in addiction has been debated for decades. Scientists and other health experts have successfully identified various risk factors for the development of addiction, but concise and objective predictors of drug addiction have eluded discovery. This past year, however, science has made significant strides in discerning how genetics may affect addiction.

A landmark scientific paper published in the April 2009 issue of Nature Reviews Genetics presented some groundbreaking new insights into the role of genetics in addiction by honing in on specific genes that are tied to all types of addictions. The study, conducted by addiction experts at the University of Virginia Health System and the University of Michigan, even found that some genes that are associated with alcohol dependence are also linked to various other  addictions. The gene was found to be a common factor in addictions to nicotine, cocaine, opioids and other substances.

Study co-author Ming Li, Ph.D., professor of psychiatry and neurobehavioral sciences at the UVA School of Medicine, commented on the study and its potential impact:

“Addiction researchers have found that several genes are linked with multiple addictions. … So, we’re narrowing the scope to specific genetic targets. Once researchers can pinpoint exact genetic variants and molecular mechanisms, then we can create much more effective, even personalized, treatments for individuals addicted to a variety of substances.”

Li also believes that further research is needed to understand the full impact of genetic variations on addiction. “The exact nature of the gene variants and how they function are still unknown, so functional studies as well as studies using additional ethnic population samples may be quite revealing,” Dr. Li said.

Another recent study, conducted by researchers at the University of Colorado in Denver, pinpointed genetic pathways and genes associated with alcohol consumption. The researchers were able to identify genetic factors that predisposed both rats and humans to drink more; however, they were unable to discover a similar link between the genes and actual alcohol addiction. Nonetheless, according to Boris Tabakoff, a lead researcher, the study’s results may help scientists to eventually connect the dots between genetic makeup and addiction.

Tabakoff said, “We know that high levels of alcohol consumption can increase the risk of becoming alcohol dependent in those who have a genetic makeup that predisposes to dependence. This is a case of interaction between genes and environment. Indeed, in our study we found that, higher alcohol consumption in humans was positively correlated with alcohol dependence. However, because different sets of genes seem to influence the level of alcohol consumption, as opposed to propensity for alcohol dependence, we are confronted with great variation in humans. Individuals with a set of genes that predisposes them to drink moderate amounts of alcohol may still have the genetic predisposition to lose control over their drinking behavior, and perhaps become alcohol dependent. Conversely, individuals with a genetic predisposition to drink high amounts of alcohol may not have the genes that predispose them to become dependent.”

A study just completed at Brown University (the results will be published in the January 2010 issue of Alcoholism: Clinical & Experimental Research) succeeded in identifying a link between a gene variation and teen alcohol misuse. For the study, researchers examined the genetic makeup of 187 adolescents (98 boys and 89 girls) around the age of 15 years. They were able to correlate a polymorphism (variation in the shape) of the OPRM1 opioid receptor gene called A118G with heightened risk for alcohol-related problems and likelihood to meet the clinical diagnostic criteria for Alcohol Use Disorder (AUD).

Robert Miranda, Jr., assistant professor in the department of psychiatry and human behavior at Brown University and corresponding author for the study, commented on the implications of the study’s findings:

“Our current knowledge about the genetics of alcohol misuse during adolescence comes almost exclusively from family and twin studies. … But the relative importance of environmental and genetic factors appears to shift considerably over the course of adolescence … with genetics playing an important role once teenagers begin to drink. … Our findings provide the first evidence to suggest that teenagers who carry a certain variant of the OPRM1 gene experience more alcohol-related problems.”

Notably, the Brown University team discovered that teens with this variant were more likely to report drinking alcohol because of the pleasurable effects than for other reasons. The fact that the genetic variation enhances the pleasure experienced by youth when consuming alcohol helps to explain why teens with this variation might be more likely to develop problem drinking behaviors.

Miranda, Jr., explains, “The G allele, or variant, of the OPRMI gene is associated with the function of the body’s own natural opiate system. Research suggests that the G allele is associated with experiencing more pleasure and greater intoxication after drinking.”

By Emily Battaglia